A machine learning model for classifying G-protein-coupled receptors as agonists or antagonists.

Journal: BMC bioinformatics
Published Date: Aug 18, 2022

Abstract

BACKGROUND: G-protein coupled receptors (GPCRs) sense and transmit extracellular signals into the intracellular machinery by regulating G proteins. GPCR malfunctions are associated with a variety of signaling-related diseases, including cancer and diabetes; at least a third of the marketed drugs target GPCRs. Thus, characterization of their signaling and regulatory mechanisms is crucial for the development of effective drugs.

Authors

  • Jooseong Oh
    School of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea.
  • Hyi-Thaek Ceong
    Department of Multimedia, Chonnam National University, Yeosu, 59626, Republic of Korea. htceong@jnu.ac.kr.
  • Dokyun Na
    School of integrative engineering, Chung-Ang University, Seoul, Republic of Korea. blisszen@cau.ac.kr.
  • Chungoo Park
    School of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea. chungoo@jnu.ac.kr.

Keywords

External Resources

Popular Topics
Recent Journals