Surgomics: personalized prediction of morbidity, mortality and long-term outcome in surgery using machine learning on multimodal data.

Journal: Surgical endoscopy
PMID: 36171451

Abstract

BACKGROUND: Personalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.

Authors

  • Martin Wagner
    Department of Biology, Norwegian University of Science and Technology, 5 Høgskoleringen, 7491 Trondheim, Norway. Electronic address: martin.wagner@ntnu.no.
  • Johanna M Brandenburg
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
  • Sebastian Bodenstedt
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • André Schulze
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Alexander C Jenke
    Department of Translational Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
  • Antonia Stern
    Corporate Research and Technology, Karl Storz SE & Co KG, Tuttlingen, Germany.
  • Marie T J Daum
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
  • Lars Mündermann
    KARL STORZ SE & Co. KG, Tuttlingen, Germany.
  • Fiona R Kolbinger
    Department of Visceral, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
  • Nithya Bhasker
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • Gerd Schneider
    Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
  • Grit Krause-Jüttler
    Department of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Hisham Alwanni
    Faculty of Engineering, University of Freiburg, Freiburg 79098, Germany. hisham.alwanni@pluto.uni-freiburg.de.
  • Fleur Fritz-Kebede
    Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
  • Oliver Burgert
    Research Group Computer Assisted Medicine (CaMed), Reutlingen University, 72762, Reutlingen, Germany.
  • Dirk Wilhelm
    Department of Surgery, Research Group Minimally Invasive Interdisciplinary Therapeutical Intervention (MITI), Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany, Department of Surgery, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany.
  • Johannes Fallert
    KARL STORZ SE & Co. KG, Tuttlingen, Germany.
  • Felix Nickel
    Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. felix.nickel@med.uni-heidelberg.de.
  • Lena Maier-Hein
    German Cancer Research Center (DKFZ), Computer Assisted Medical Interventions, Heidelberg, Germany.
  • Martin Dugas
    Institute of Medical Informatics, Heidelberg University, Heidelberg, Germany.
  • Marius Distler
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Jürgen Weitz
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Beat-Peter Müller-Stich
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
  • Stefanie Speidel
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.

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