Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modeling.

Journal: Bioinformatics (Oxford, England)
Published Date: Sep 15, 2022

Abstract

MOTIVATION: Recent development of deep-learning methods has led to a breakthrough in the prediction accuracy of 3D protein structures. Extending these methods to protein pairs is expected to allow large-scale detection of protein-protein interactions (PPIs) and modeling protein complexes at the proteome level.

Authors

  • Jimin Pei
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jing Zhang
    MOEMIL Laboratory, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu, China.
  • Qian Cong
    Department of Biochemistry, Seattle, WA 98105, USA.

Keywords

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