Defining the characteristics of interferon-alpha-stimulated human genes: insight from expression data and machine learning.

Journal: GigaScience
PMID: 36399061

Abstract

BACKGROUND: A virus-infected cell triggers a signalling cascade, resulting in the secretion of interferons (IFNs), which in turn induces the upregulation of the IFN-stimulated genes (ISGs) that play a role in antipathogen host defence. Here, we conducted analyses on large-scale data relating to evolutionary gene expression, sequence composition, and network properties to elucidate factors associated with the stimulation of human genes in response to IFN-α.

Authors

  • Haiting Chai
    School of Computer Science and Information Technology, Northeast Normal University, Changchun, 130117, China.
  • Quan Gu
    MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, Garscube Campus, Campus, 464 Bearsden Road, Glasgow, G61 1QH, Scotland, UK.
  • David L Robertson
    MRC-University of Glasgow Centre For Virus Research, Glasgow, United Kingdom.
  • Joseph Hughes
    MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, Garscube Campus, Campus, 464 Bearsden Road, Glasgow, G61 1QH, Scotland, UK.

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