Performance analysis of seven Convolutional Neural Networks (CNNs) with transfer learning for Invasive Ductal Carcinoma (IDC) grading in breast histopathological images.

Journal: Scientific reports
Published Date:

Abstract

Computer-aided Invasive Ductal Carcinoma (IDC) grading classification systems based on deep learning have shown that deep learning may achieve reliable accuracy in IDC grade classification using histopathology images. However, there is a dearth of comprehensive performance comparisons of Convolutional Neural Network (CNN) designs on IDC in the literature. As such, we would like to conduct a comparison analysis of the performance of seven selected CNN models: EfficientNetB0, EfficientNetV2B0, EfficientNetV2B0-21k, ResNetV1-50, ResNetV2-50, MobileNetV1, and MobileNetV2 with transfer learning. To implement each pre-trained CNN architecture, we deployed the corresponded feature vector available from the TensorFlowHub, integrating it with dropout and dense layers to form a complete CNN model. Our findings indicated that the EfficientNetV2B0-21k (0.72B Floating-Point Operations and 7.1 M parameters) outperformed other CNN models in the IDC grading task. Nevertheless, we discovered that practically all selected CNN models perform well in the IDC grading task, with an average balanced accuracy of 0.936 ± 0.0189 on the cross-validation set and 0.9308 ± 0.0211on the test set.

Authors

  • Wingates Voon
    Department of Mechatronics and Biomedical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Sungai Long, Malaysia.
  • Yan Chai Hum
    Department of Mechatronics and Biomedical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Cheras, 43000 Kajang, Selangor Darul Ehsan, Malaysia.
  • Yee Kai Tee
    Department of Mechatronics & Biomedical Engineering, Universiti Tunku Abdul Rahman, Sungai Long 43000, Malaysia.
  • Wun-She Yap
    Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Malaysia. Electronic address: yapws@utar.edu.my.
  • Maheza Irna Mohamad Salim
    Diagnostic Research Group, School of Biomedical Engineering and Health Sciences, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, 81300, Skudai, Johor, Malaysia.
  • Tian Swee Tan
    BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, 81300, Skudai, Johor, Malaysia.
  • Hamam Mokayed
    Department of Computer Science, Electrical and Space Engineering, Lulea University of Technology, Luleå, Sweden.
  • Khin Wee Lai
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.