DeepFundus: A flow-cytometry-like image quality classifier for boosting the whole life cycle of medical artificial intelligence.

Journal: Cell reports. Medicine
Published Date: Jan 19, 2023

Abstract

Medical artificial intelligence (AI) has been moving from the research phase to clinical implementation. However, most AI-based models are mainly built using high-quality images preprocessed in the laboratory, which is not representative of real-world settings. This dataset bias proves a major driver of AI system dysfunction. Inspired by the design of flow cytometry, DeepFundus, a deep-learning-based fundus image classifier, is developed to provide automated and multidimensional image sorting to address this data quality gap. DeepFundus achieves areas under the receiver operating characteristic curves (AUCs) over 0.9 in image classification concerning overall quality, clinical quality factors, and structural quality analysis on both the internal test and national validation datasets. Additionally, DeepFundus can be integrated into both model development and clinical application of AI diagnostics to significantly enhance model performance for detecting multiple retinopathies. DeepFundus can be used to construct a data-driven paradigm for improving the entire life cycle of medical AI practice.

Authors

  • Lixue Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  • Xiaohang Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Xian Lie South Road 54#, Guangzhou, 510060, China.
  • Duoru Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Lanqin Zhao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
  • Mingyuan Li
  • Dongyuan Yun
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Zhenzhe Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China.
  • Jianyu Pang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.
  • Longhui Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.
  • Yuxuan Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  • Weiyi Lai
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Wei Xiao
    Department of Emergency Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhenjiang Province, China.
  • Yuanjun Shang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.
  • Weibo Feng
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, 510060, China.
  • Xiao Tan
    College of Food Science and Engineering, Northwest University, Xi'an 710069, China; School of Chemistry & Chemical Engineering, Yulin University, Yulin 719000, China.
  • Qiang Li
    Department of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.
  • Shenzhen Liu
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Xinxin Lin
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Jiaxin Sun
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Yiqi Zhao
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Ximei Yang
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Qinying Ye
    Department of Ophthalmology, Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.
  • Yuesi Zhong
    Department of Ophthalmology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Xi Huang
    Institute of Computing Technology(ICT), Chinese Academy of Sciences(CAS), Beijing, China.
  • Yuan He
    Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, PR China. Electronic address: heyuan@301hospital.com.cn.
  • Ziwei Fu
    Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, China.
  • Yi Xiang
    Department of Ophthalmology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Li Zhang
    Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  • Mingwei Zhao
    Department of Ophthalmology, Ophthalmology and Optometry Centre, Peking University People's Hospital, Beijing, China.
  • Jinfeng Qu
    Department of Ophthalmology, People's Hospital of Peking University, Beijing, China.
  • Fan Xu
    Department of Public Health, Chengdu Medical College, Sichuan, China.
  • Peng Lu
    Department of Industrial Design, Dalian University of Technology, Dalian 116024, China.
  • Jianqiao Li
    Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
  • Fabao Xu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • Wenbin Wei
    Clinical Center for Eye Tumors, Capital Medical University, Beijing, 100730, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Stree, Dongcheng District, Beijing, 100730, China; Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China. Electronic address: weiwenbintr@163.com.
  • Li Dong
    Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China. donglikn199@163.com.
  • Guangzheng Dai
    The Second Clinical College, Dalian Medical University, Dalian, Liaoning, China.
  • Xingru He
    School of Public Health, He University, Shenyang, Liaoning, China.
  • Wentao Yan
    The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Qiaolin Zhu
    The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Linna Lu
    Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Jiaying Zhang
    School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • Wei Zhou
    Department of Eye Function Laboratory, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  • Xiangda Meng
    Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
  • Shiying Li
    Imaging and Data Science Laboratory Department of Biomedical Engineering University of Virginia.
  • Mei Shen
    Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China.
  • Qin Jiang
    The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.
  • Nan Chen
  • Xingtao Zhou
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
  • Meiyan Li
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • HaoHan Zou
    Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
  • Hua Zhong
    Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
  • Wenyan Yang
    Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Wulin Shou
    Jiaxing Chaoju Eye Hospital, Jiaxing, Zhejiang, China.
  • Xingwu Zhong
    Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, Hainan, China.
  • Zhenduo Yang
    Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, Hainan, China.
  • Lin Ding
    Faculty of Psychology, Tianjin Normal University, Tianjin, China.
  • Yongcheng Hu
    Bayannur Paralympic Eye Hospital, Bayannur, Inner Mongolia, China.
  • Gang Tan
    Department of Ophthalmology, University of South China, Hengyang, Hunan, China.
  • Wanji He
    Beijing Airdoc Technology Co., Ltd., Beijing, China.
  • Xin Zhao
    Florida International University.
  • Yuzhong Chen
    School of Material Science and Engineering, Shandong University, Jinan, China.
  • Yizhi Liu
    School of Computer Science and Engineering, Hunan University of Science and Technology, Xiangtan, China.
  • Haotian Lin
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou.

Keywords

External Resources

Popular Topics
Recent Journals