Sulfur-containing marine natural products as leads for drug discovery and development.

Journal: Current opinion in chemical biology
PMID: 37257309

Abstract

Among the large series of marine natural products (MNPs), sulfur-containing MNPs have emerged as potential therapeutic agents for the treatment of a range of diseases. Herein, we reviewed 95 new sulfur-containing MNPs isolated during the period between 2021 and March 2023. In addition, we discuss that the widely used strategies and the emerging technologies including natural product-based antibody drug conjugates (ADCs), small-molecule-based proteolysis targeting chimeras (PROTACs), nanotechnology-based drug carriers, artificial intelligence (AI)-driven drug discovery have been used for improving the efficiency and success rate of NP-based drug development. We also provide perspectives regarding the challenges and opportunities in sulfur-containing MNPs based drug discovery and development and future research directions.

Authors

  • Feng-Wei Guo
    Key Laboratory of Marine Drugs, The Ministry of Education of China School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laoshan Laboratory, Qingdao, 266237, China.
  • Qun Zhang
    School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 201100, China.
  • Yu-Cheng Gu
    Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK. Electronic address: yucheng.gu@syngenta.com.
  • Chang-Lun Shao
    Key Laboratory of Marine Drugs, The Ministry of Education of China School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laoshan Laboratory, Qingdao, 266237, China. Electronic address: shaochanglun@163.com.

Keywords

External Resources

Popular Topics
Recent Journals