Recent advances in measurement of metabolic clearance, metabolite profile and reaction phenotyping of low clearance compounds.
Journal:
Expert opinion on drug discovery
PMID:
37526497
Abstract
INTRODUCTION: Low metabolic clearance is usually a highly desirable property of drug candidates in order to reduce dose and dosing frequency. However, measurement of low clearance can be challenging in drug discovery. A number of new tools have recently been developed to address the gaps in the measurement of intrinsic clearance, identification of metabolites, and reaction phenotyping of low clearance compounds.