Geographic Atrophy Segmentation Using Multimodal Deep Learning.

Journal: Translational vision science & technology
Published Date:

Abstract

PURPOSE: To examine deep learning (DL)-based methods for accurate segmentation of geographic atrophy (GA) lesions using fundus autofluorescence (FAF) and near-infrared (NIR) images.

Authors

  • Theodore Spaide
    Department of Ophthalmology, School of Medicine, University of Washington, Seattle, WA, USA.
  • Jiaxiang Jiang
    Clinical Imaging Group, Genentech, Inc., South San Francisco, CA, USA.
  • Jasmine Patil
    Clinical Imaging Group, Genentech, Inc., South San Francisco, CA, USA.
  • Neha Anegondi
    Clinical Imaging Group, Genentech, Inc., South San Francisco, California; Roche Ophthalmology Personalized Healthcare, Genentech, Inc., South San Francisco, California.
  • Verena Steffen
    gRED Computational Science, Genentech, Inc., South San Francisco, California.
  • Michael G Kawczynski
    From the Department of Radiology and Biomedical Imaging (Y.D., J.H.S., H.T., R.H., N.W.J., T.P.C., M.S.A., C.M.A., S.C.B., R.R.F., S.Y.H., Y.S., R.A.H., M.H.P., B.L.F.) and Institute for Computational Health Sciences (J.H.S., M.G.K., H.T., D.L., K.A.Z., D.H.), University of California, San Francisco, 550 Parnassus Ave, San Francisco, CA 94143; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, Calif (Y.D.); and Department of Radiology, University of California, Davis, Sacramento, Calif (L.N.).
  • Elizabeth M Newton
    Genentech, Inc., South San Francisco, California.
  • Christina Rabe
    Roche Ophthalmology Personalized Healthcare, Genentech, Inc., South San Francisco, California; Biostatistics, Genentech, Inc., South San Francisco, California.
  • Simon S Gao
    gRED Computational Science, Genentech, Inc., South San Francisco, California.
  • Aaron Y Lee
    Department of Ophthalmology, University of Washington, Seattle, Washington.
  • Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany.
  • Srinivas Sadda
    Doheny Eye Institute, Los Angeles, CA, 90033, USA.
  • Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany; GRADE Reading Center, Bonn, Germany; John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Electronic address: Steffen.schmitz-valckenberg@ukbonn.de.
  • Daniela Ferrara
    Genentech, Inc., South San Francisco, California.