Combination of deep XLMS with deep learning reveals an ordered rearrangement and assembly of a major protein component of the vaccinia virion.

Journal: mBio
PMID: 37646531

Abstract

An outstanding problem in the understanding of poxvirus biology is the molecular structure of the mature virion. Via deep learning methods combined with chemical cross-linking mass spectrometry, we have addressed the structure and assembly pathway of P4a, a key poxvirus virion core component.

Authors

  • Yeva Mirzakhanyan
    Department of Molecular Biology and Biochemistry, University of California Irvine , Irvine, California, USA.
  • Andris Jankevics
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht , Utrecht, the Netherlands.
  • Richard A Scheltema
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands.
  • Paul David Gershon
    Department of Molecular Biology and Biochemistry, University of California Irvine , Irvine, California, USA.

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