Deep multi-task learning for nephropathy diagnosis on immunofluorescence images.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVE: As an advanced technique, immunofluorescence (IF) is one of the most widely-used medical image for nephropathy diagnosis, due to its ease of acquisition with low cost. In practice, the clinically collected IF images are commonly corrupted by blurs at different degrees, mainly because of the inaccurate focus at the acquisition stage. Although deep neural network (DNN) methods achieve the great success in nephropathy diagnosis, their performance dramatically drops over the blurred IF images. This significantly limits the potential of leveraging the advanced DNN techniques in real-world nephropathy diagnosis scenarios.

Authors

  • Yibing Fu
    School of Electronic and Information Engineering, Beihang University, Beijing, China.
  • Lai Jiang
  • Sai Pan
    Department of Nephrology, Chinese People's Liberation Army General Hospital, Beijing, China.
  • Pu Chen
    Department of Biomedical Engineering, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
  • Xiaofei Wang
    Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Ning Dai
    College of Mechanical & Electrical Engineering, Nanjing University of Aeronautics & Astronautics, 210016, Nanjing, P.R. China.
  • Xiangmei Chen
    Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
  • Mai Xu