Development and Validation of a Deep Learning-Based Histologic Diagnosis System for Diagnosing Colorectal Sessile Serrated Lesions.

Journal: American journal of clinical pathology
Published Date:

Abstract

OBJECTIVES: The histopathologic diagnosis of colorectal sessile serrated lesions (SSLs) and hyperplastic polyps (HPs) is of low consistency among pathologists. This study aimed to develop and validate a deep learning (DL)-based logical anthropomorphic pathology diagnostic system (LA-SSLD) for the differential diagnosis of colorectal SSL and HP.

Authors

  • Zhifeng Wu
    From the Department of Radiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University.
  • Liwen Yao
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wen Liu
    Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
  • Shiying Zhang
    Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Lihui Zhang
    College of Civil Engineering and Architecture, Zhejiang University, 866, Yuhangtang Road, Hangzhou, 310058, China.
  • Zihua Lu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Jing Wang
    Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing, China.
  • Boru Chen
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Renquan Luo
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Xun Li
    Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Rongrong Gong
    Department of Gastroenterology, Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, and Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China.
  • Chaijie Luo
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Youming Xu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhi Zeng
    Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Honggang Yu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.