ORI-Explorer: a unified cell-specific tool for origin of replication sites prediction by feature fusion.

Journal: Bioinformatics (Oxford, England)
PMID: 37929975

Abstract

MOTIVATION: The origins of replication sites (ORIs) are precise regions inside the DNA sequence where the replication process begins. These locations are critical for preserving the genome's integrity during cell division and guaranteeing the faithful transfer of genetic data from generation to generation. The advent of experimental techniques has aided in the discovery of ORIs in many species. Experimentation, on the other hand, is often more time-consuming and pricey than computational approaches, and it necessitates specific equipment and knowledge. Recently, ORI sites have been predicted using computational techniques like motif-based searches and artificial intelligence algorithms based on sequence characteristics and chromatin states.

Authors

  • Zeeshan Abbas
    Department of Electronics and Information Engineering, Jeonbuk National University, Jeonju 54896, Korea.
  • Mobeen Ur Rehman
  • Hilal Tayara
    Department of Electronics and Information Engineering, Chonbuk National University, Jeonju 54896, South Korea. Electronic address: hilaltayara@jbnu.ac.kr.
  • Kil To Chong
    Division of Electronic Engineering, and Advanced Research Center of Electronics and Information, Chonbuk National University, Jeonju-Si 54896, South Korea. Electronic address: kitchong@jbnu.ac.kr.

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