Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.

Journal: Cardiovascular & hematological disorders drug targets
Published Date: Jan 1, 2024

Abstract

BACKGROUND: Premature Ovarian Insufficiency (POI) is associated with infertility. Little is known about the potential circulating biomarkers that could be used to predict POI. We have investigated the possible association between white and red blood cells, platelet indices, and eight established single nucleotide polymorphisms (SNPs) associated with POI risk.

Authors

  • Mohammad Reza Mirinezhad
    Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Malihe Aghasizadeh
    Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hamideh Ghazizadeh
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad 917791-8564, Iran.
  • Anahid Hemmatpur
    Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
  • Mohammad Reza Fazl Mashhadi
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hamed Khedmatgozar
    Center for Biotechnology and Genomics, Texas Tech University, TX79409, Lubbock, TX79409, USA.
  • Amir Kiyoumarsioskouei
    Faculty of Mechanical Engineering, Sahand University of Technology, Tabriz, Iran.
  • Ali Ebrahimi Dabagh
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad Amin Mohammadi
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Arezoo Rastegarmoghadam Ebrahimian
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Melika Malek
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sara Moazedi
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Simin Rashidian
    International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Gordon A Ferns
    Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
  • Tayebeh Hamzehloei
    Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Alireza Pasdar
    Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Majid Ghayour-Mobarhan
    International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

Keywords

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