DrugBank 6.0: the DrugBank Knowledgebase for 2024.

Journal: Nucleic acids research
Published Date: Jan 5, 2024

Abstract

First released in 2006, DrugBank (https://go.drugbank.com) has grown to become the 'gold standard' knowledge resource for drug, drug-target and related pharmaceutical information. DrugBank is widely used across many diverse biomedical research and clinical applications, and averages more than 30 million views/year. Since its last update in 2018, we have been actively enhancing the quantity and quality of the drug data in this knowledgebase. In this latest release (DrugBank 6.0), the number of FDA approved drugs has grown from 2646 to 4563 (a 72% increase), the number of investigational drugs has grown from 3394 to 6231 (a 38% increase), the number of drug-drug interactions increased from 365 984 to 1 413 413 (a 300% increase), and the number of drug-food interactions expanded from 1195 to 2475 (a 200% increase). In addition to this notable expansion in database size, we have added thousands of new, colorful, richly annotated pathways depicting drug mechanisms and drug metabolism. Likewise, existing datasets have been significantly improved and expanded, by adding more information on drug indications, drug-drug interactions, drug-food interactions and many other relevant data types for 11 891 drugs. We have also added experimental and predicted MS/MS spectra, 1D/2D-NMR spectra, CCS (collision cross section), RT (retention time) and RI (retention index) data for 9464 of DrugBank's 11 710 small molecule drugs. These and other improvements should make DrugBank 6.0 even more useful to a much wider research audience ranging from medicinal chemists to metabolomics specialists to pharmacologists.

Authors

  • Craig Knox
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Mike Wilson
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Christen M Klinger
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Mark Franklin
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Eponine Oler
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
  • Alex Wilson
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Allison Pon
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Jordan Cox
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Na Eun Lucy Chin
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Seth A Strawbridge
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Marysol Garcia-Patino
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Ray Kruger
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Aadhavya Sivakumaran
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Selena Sanford
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Rahil Doshi
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Nitya Khetarpal
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Omolola Fatokun
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Daphnee Doucet
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Ashley Zubkowski
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Dorsa Yahya Rayat
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Hayley Jackson
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Karxena Harford
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Afia Anjum
    Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Mahi Zakir
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Fei Wang
    Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.
  • Siyang Tian
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Brian Lee
  • Jaanus Liigand
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E8, Canada.
  • Harrison Peters
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
  • Ruo Qi Rachel Wang
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Tue Nguyen
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Denise So
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Matthew Sharp
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Rodolfo da Silva
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Cyrella Gabriel
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Joshua Scantlebury
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Marissa Jasinski
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • David Ackerman
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Timothy Jewison
    OMx Personal Health Analytics, Inc., 700-10130 103 St NW, Edmonton, AB T5J 1B9, Canada.
  • Tanvir Sajed
    Department of Computer Science, University of Alberta, Edmonton, AB, Canada. Tsajed@ualberta.ca.
  • Vasuk Gautam
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E8, Canada.
  • David S Wishart
    Departments of Biological Sciences and Computing Science, University of Alberta , Edmonton, Alberta T6G 2E9, Canada.

Keywords

External Resources

Popular Topics
Recent Journals