Federated machine learning in healthcare: A systematic review on clinical applications and technical architecture.

Journal: Cell reports. Medicine
Published Date:

Abstract

Federated learning (FL) is a distributed machine learning framework that is gaining traction in view of increasing health data privacy protection needs. By conducting a systematic review of FL applications in healthcare, we identify relevant articles in scientific, engineering, and medical journals in English up to August 31st, 2023. Out of a total of 22,693 articles under review, 612 articles are included in the final analysis. The majority of articles are proof-of-concepts studies, and only 5.2% are studies with real-life application of FL. Radiology and internal medicine are the most common specialties involved in FL. FL is robust to a variety of machine learning models and data types, with neural networks and medical imaging being the most common, respectively. We highlight the need to address the barriers to clinical translation and to assess its real-world impact in this new digital data-driven healthcare scene.

Authors

  • Zhen Ling Teo
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Liyuan Jin
    Duke-NUS Medical School, Singapore, Singapore.
  • Siqi Li
    Software College, Northeastern University, Shenyang 110819, China.
  • Di Miao
    School of Electronic Engineering, Tianjin University of Technology and Education, Tianjin, China.
  • Xiaoman Zhang
    Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Wei Yan Ng
    Duke-NUS Medical School, National University of Singapore.
  • Ting Fang Tan
    Singapore National Eye Center, Singapore Eye Research Institute Singapore Health Service Singapore Singapore.
  • Deborah Meixuan Lee
    Singapore Eye Research Institute, Singapore, Singapore; Institute of High Performance Computing, Agency for Science, Technology and Research, Singapore, Singapore.
  • Kai Jie Chua
    Singapore National Eye Centre, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore.
  • John Heng
    Singapore National Eye Centre, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore.
  • Yong Liu
    Department of Critical care medicine, Shenzhen Hospital, Southern Medical University, Guangdong, Shenzhen, China.
  • Rick Siow Mong Goh
    A*STAR, Singapore, Singapore.
  • Daniel Shu Wei Ting
    Singapore National Eye Center, Singapore Eye Research Institute Singapore Health Service Singapore Singapore.