Enabling personalised disease diagnosis by combining a patient's time-specific gene expression profile with a biomedical knowledge base.
Journal:
BMC bioinformatics
Published Date:
Feb 7, 2024
Abstract
BACKGROUND: Recent developments in the domain of biomedical knowledge bases (KBs) open up new ways to exploit biomedical knowledge that is available in the form of KBs. Significant work has been done in the direction of biomedical KB creation and KB completion, specifically, those having gene-disease associations and other related entities. However, the use of such biomedical KBs in combination with patients' temporal clinical data still largely remains unexplored, but has the potential to immensely benefit medical diagnostic decision support systems.