Blueprints from plane to space: outlook of next-generation three-dimensional histopathology.

Journal: Cancer science
Published Date:

Abstract

Here, we summarize the literature relevant to recent advances in three-dimensional (3D) histopathology in relation to clinical oncology, highlighting serial sectioning, tissue clearing, light-sheet microscopy, and digital image analysis with artificial intelligence. We look forward to a future where 3D histopathology expands our understanding of human pathophysiology and improves patient care through cross-disciplinary collaboration and innovation.

Authors

  • Akira Leon Yoshikawa
    Department of Biochemistry and Systems Biomedicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Takaki Omura
    Department of Biochemistry and Systems Biomedicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Atsushi Takahashi-Kanemitsu
    Department of Biochemistry and Systems Biomedicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Etsuo A Susaki
    Department of Systems Pharmacology, The University of Tokyo Graduate School of Medicine.