CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides.

Journal: Briefings in bioinformatics
Published Date: Mar 27, 2024

Abstract

Cyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development. However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https://www.biosino.org/iMAC/cyclicpepedia/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides' sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development.

Authors

  • Lei Liu
    Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Liu Yang
    Department of Ultrasound, Hunan Children's Hospital, Changsha, China.
  • Suqi Cao
    National Center, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, P. R. China.
  • Zhigang Gao
    Department of General Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
  • Bin Yang
    School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, PR China. Electronic address: yangbin@dlut.edu.cn.
  • Guoqing Zhang
    Department of Anesthesiology, Zhumadian Central Hospital, Zhumadian, Henan Province, China. Electronic address: hubywk@163.com.
  • Ruixin Zhu
    Tongji University, Shanghai, China.
  • Dingfeng Wu
    Tongji University, Shanghai, China.

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