Machine learning-based longitudinal prediction for GJB2-related sensorineural hearing loss.

Journal: Computers in biology and medicine
PMID:

Abstract

BACKGROUND: Recessive GJB2 variants, the most common genetic cause of hearing loss, may contribute to progressive sensorineural hearing loss (SNHL). The aim of this study is to build a realistic predictive model for GJB2-related SNHL using machine learning to enable personalized medical planning for timely intervention.

Authors

  • Pey-Yu Chen
    Department of Otolaryngology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City, Taiwan; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
  • Ta-Wei Yang
    Graduate Institute of Networking and Multimedia, National Taiwan University, Taipei, Taiwan.
  • Yi-Shan Tseng
    Department of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
  • Cheng-Yu Tsai
    Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Chiung-Szu Yeh
    Department of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
  • Yen-Hui Lee
    Department of Otolaryngology, National Taiwan University Biomedical Park Hospital, Hsinchu County, Taiwan; Department of Otolaryngology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan; Hearing and Speech Center, National Taiwan University Hospital, Taipei, Taiwan.
  • Pei-Hsuan Lin
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Ting-Chun Lin
    Department of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
  • Yu-Jen Wu
    Department of Medical Imaging, Renai Branch, Taipei City Hospital, Taipei, Taiwan.
  • Ting-Hua Yang
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
  • Yu-Ting Chiang
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Jacob Shu-Jui Hsu
    Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Chuan-Jen Hsu
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Department of Otorhinolaryngology-Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
  • Pei-Lung Chen
    Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Chen-Fu Chou
    Department of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
  • Chen-Chi Wu
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan. Electronic address: chenchiwu@ntuh.gov.tw.