Interferon-α and inosine pranobex-mediated inhibition of reploication of human RNA viruses in vitro.
Journal:
Medycyna doswiadczalna i mikrobiologia
PMID:
28146624
Abstract
INTRODUCTION: Interferon- a (IFN-a), produced by immune cells, exhibits pleiotropic anti- viral activity. Inosine pranobex (PI), a synthetic derivative of a purine, shows direct anti- viral activity, and also acts indirectly, by activation of immune cells. The aim of this study was to evaluate an in vitro inhibition of Coxackievirus A16 (CAI6), enterovirus 71 (EV71) and human parainfluenza virus 4 (HPIV-4) replication by PI in combination with IFN-a.