VascuConNet: an enhanced connectivity network for vascular segmentation.

Journal: Medical & biological engineering & computing
Published Date:

Abstract

Medical image segmentation commonly involves diverse tissue types and structures, including tasks such as blood vessel segmentation and nerve fiber bundle segmentation. Enhancing the continuity of segmentation outcomes represents a pivotal challenge in medical image segmentation, driven by the demands of clinical applications, focusing on disease localization and quantification. In this study, a novel segmentation model is specifically designed for retinal vessel segmentation, leveraging vessel orientation information, boundary constraints, and continuity constraints to improve segmentation accuracy. To achieve this, we cascade U-Net with a long-short-term memory network (LSTM). U-Net is characterized by a small number of parameters and high segmentation efficiency, while LSTM offers a parameter-sharing capability. Additionally, we introduce an orientation information enhancement module inserted into the model's bottom layer to obtain feature maps containing orientation information through an orientation convolution operator. Furthermore, we design a new hybrid loss function that consists of connectivity loss, boundary loss, and cross-entropy loss. Experimental results demonstrate that the model achieves excellent segmentation outcomes across three widely recognized retinal vessel segmentation datasets, CHASE_DB1, DRIVE, and ARIA.

Authors

  • Muwei Jian
    School of Computer Science and Technology, Shandong University of Finance and Economics, Jinan 250014, China.
  • Ronghua Wu
    School of Information Science and Technology, Linyi University, Linyi, China.
  • Wenjin Xu
    School of Information Science and Technology, Linyi University, Linyi, China.
  • Huixiang Zhi
    School of Information Science and Technology, Linyi University, Linyi, China.
  • Chen Tao
    Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
  • Hongyu Chen
    Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
  • Xiaoguang Li
    Huzhou Key Laboratory of Green Energy Materials and Battery Cascade Utilization, School of Intelligent Manufacturing, Huzhou College, Huzhou, China.