Drug repurposing based on the DTD-GNN graph neural network: revealing the relationships among drugs, targets and diseases.

Journal: BMC genomics
Published Date: Jun 11, 2024

Abstract

MOTIVATION: The rational modelling of the relationship among drugs, targets and diseases is crucial for drug retargeting. While significant progress has been made in studying binary relationships, further research is needed to deepen our understanding of ternary relationships. The application of graph neural networks in drug retargeting is increasing, but further research is needed to determine the appropriate modelling method for ternary relationships and how to capture their complex multi-feature structure.

Authors

  • Wenjun Li
    Key Laboratory of RF Circuits and Systems, Ministry of Education, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
  • Wanjun Ma
    Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, Hunan, China.
  • Mengyun Yang
  • Xiwei Tang

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