We have recently identified a new class of filamenting temperature-sensitive mutant Z (FtsZ)-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine-quinuclidine scaffold with moderate antibacterial activity. Employing this scaffold as a...
: Prostate-specific membrane antigen (PSMA) has gained high attention as a useful biomarker in the imaging evaluation of prostate cancer with positron emission tomography (PET) during recent years. [Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([Ga]-PSMA-HB...
We report the fabrication of immunosensors based on nanostructured mats of electrospun nanofibers of polyamide 6 and poly(allylamine hydrochloride) coated either with multiwalled carbon nanotubes (MWCNTs) or gold nanoparticles (AuNPs), whose three-di...
In recent decades, drug delivery systems (DDSs) based on polymer nanoparticles have been explored due to their potential to deliver drugs with poor water solubility. Some of the limitations of nanoparticle-based DDSs can be overcome by developing an ...
In computational chemistry and chemoinformatics, the support vector machine (SVM) algorithm is among the most widely used machine learning methods for the identification of new active compounds. In addition, support vector regression (SVR) has become...
Tracking dynamic cellular processes necessitates fluorescent materials that are photostable, biocompatible, water-soluble, nanosized, and nontoxic. In this study, highly fluorescent carbon dots (CDs) were produced from cheap and readily available sou...
Easily accessible 3,3'-diindolylmethanes (DIMs) were utilized to generate a focused library of indolo[2,3-]quinolines (), chromeno[2,3-]indoles (), and 3-alkenyl-oxindoles () under 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxidative co...
The NusB-NusE protein-protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription in all bacteria. This PPI is an emerging antibacterial drug target. Pharmacophore-based screening o...
Cu clusters on ZnO have been prepared by a simple low-temperature solid-state reaction from their respective acetate precursors. The formation of metallic Cu along with a small quantity of CuO was influenced by the presence of the zinc acetate precur...