Frontiers in pharmacology
Jan 3, 2025
The efficacy of many compounds against is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been investigated to achieve high local the...
Frontiers in pharmacology
Dec 24, 2024
The latest breakthroughs in information technology and biotechnology have catalyzed a revolutionary shift within the modern healthcare landscape, with notable impacts from artificial intelligence (AI) and deep learning (DL). Particularly noteworthy i...
Frontiers in pharmacology
Dec 23, 2024
INTRODUCTION: Diabetic retinopathy is a significant microvascular disorder and the leading cause of vision impairment in working-age individuals. Hyperglycemia triggers retinal damage through mechanisms such as the polyol pathway and the accumulation...
Frontiers in pharmacology
Dec 19, 2024
Monkeypox, a zoonotic virus in the , has drawn global attention for its impact on public health. In the current Mpox outbreak, a novel clade, Ib, has emerged as a significant and potentially fatal threat. This review examines the dynamics of MPXV tra...
Frontiers in pharmacology
Dec 19, 2024
BACKGROUND: Sika deer (, 1838) antler is a highly esteemed tonic renowned for its abundant assortment of polypeptides, polysaccharides, amino acids, and minerals, and is recognized for its multifarious pharmacological properties. However, limited res...
Frontiers in pharmacology
Dec 19, 2024
INTRODUCTION: MRTX1133 is a selective and reversible small molecule inhibitor of KRAS (G12D), which significantly delays the progression of solid tumors. However, no study on the absorption, distribution, and excretion of MRTX1133.
Frontiers in pharmacology
Dec 19, 2024
INTRODUCTION: Ischemic stroke greatly threatens human life and health. Neuro-restoration is considered to be the critical points in reestablishing neurological function and improving the quality of life of patients. Catalpol is the main active ingred...
Frontiers in pharmacology
Dec 18, 2024
Obesity, a growing global health concern, is linked to severe ailments such as cardiovascular diseases, type 2 diabetes, cancer, and neuropsychiatric disorders. Conventional pharmacological treatments often have significant side effects, highlighting...
Frontiers in pharmacology
Dec 18, 2024
AIMS: Few personalized monitoring models for valproic acid (VPA) in pediatric epilepsy patients (PEPs) incorporate machine learning (ML) algorithms. This study aimed to develop an ensemble ML model for VPA monitoring to enhance clinical precision of ...
Frontiers in pharmacology
Dec 18, 2024
INTRODUCTION: The mechanism of tannic acid (TA) intervention on methicillin-resistant (MRSA, USA 300) biofilm formation was explored using proteomics.