Frontiers in pharmacology
Jan 22, 2020
Despite some previous examples of successful application to the field of pharmacogenomics, the utility of machine learning (ML) techniques for warfarin dose predictions in Caribbean Hispanic patients has yet to be fully evaluated. This study compares...
Frontiers in pharmacology
Jan 15, 2020
Antimalarial drugs are becoming less effective due to the emergence of drug resistance. Resistance has been reported for all available malaria drugs, including artemisinin, thus creating a perpetual need for alternative drug candidates. The tradition...
Frontiers in pharmacology
Jan 28, 2019
Apolipoprotein A1 (ApoA1) is remarkably decreased in serum and ovarian tissues of ovarian cancer patients. ApoA1 and ApoA1 mimetic peptides can sequestrate pro-inflammatory phospholipids, some of which are known to activate a variety of oncogenic pa...
Frontiers in pharmacology
Jan 22, 2019
Superparamagnetic iron-oxide nanoparticle (SPION) has gained tremendous attention for drug delivery applications due to their unique properties. In this study, we developed a dual targeted delivery system with paclitaxel (PTX) and SPION co-loaded PLG...
Frontiers in pharmacology
Jan 17, 2019
Aflatoxin B (AFB) is one of the most hazardous mycotoxins contamination in food and feed products, which leads to hepatocellular carcinoma in humans and animals. In the present study, we isolated and characterized an AFB degrading bacteria CG1061 fro...
Frontiers in pharmacology
Jan 15, 2019
Alcalase, dispase, trypsin, and flavourzyme were used to hydrolyze the extracted seeds protein isolate (GPI). The protein hydrolyzates (GPHs) with the maximum degree of hydrolysis (DH) and ACE inhibitory activity were selected, and ultra-filtered t...
Frontiers in pharmacology
Jan 9, 2019
This study presented a rapid, simple and environmentally friendly method of employing AQ C-based vortex-homogenized matrix solid-phase dispersion with ionic liquid (AQ C-IL-VHMSPD) for the extraction of compounds with different polarities from Platyc...
Frontiers in pharmacology
Jan 8, 2019
Ciji-Hua'ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medical formula that has been shown in clinical practice to relieve side effects of chemotherapy and improve quality of life for cancer patients. In order to understand the mechanism...
Frontiers in pharmacology
Jan 4, 2019
Bovine respiratory disease (BRD) is the most common infectious disease in dairy and beef cattle. It is associated with significant morbidity and mortality and causes a huge economic loss each year. In western Canada, a one-time injection of tulathrom...
Frontiers in pharmacology
Dec 12, 2017
This study aims to evaluate the cytotoxic and anti-migratory effects of L. on prostate cancer cells, identify the active compound/s and characterize their mechanism of actions. Two farmed varieties were studied, var. (FD1) and var. (FD2). Their c...