AI Medical Compendium Journal:
International journal of clinical and experimental medicine

Showing 11 to 20 of 20 articles

Higher serum total bilirubin concentration is associated with lower risk of renal insufficiency in an adult population.

International journal of clinical and experimental medicine
BACKGROUND: Chronic inflammation is proposed to play a central role in the pathogenesis of chronic kidney disease (CKD), and serum bilirubin has antioxidant and anti-inflammatory effects. We investigated the association between serum total bilirubin ...

Polyphylla saponin I has antiviral activity against influenza A virus.

International journal of clinical and experimental medicine
OBJECTIVE: In the present study, the antiviral effects of polyphylla saponin I isolated from Parispolyphylla on influenza A virus are investigated both in vitro and in vivo.

Intact parathormone measurement 1 hour after total thyroidectomy as a predictor of symptomatic hypocalcemia.

International journal of clinical and experimental medicine
OBJECTIVE: Postoperative iPTH assay may predict significant hypocalcemia after thyroid surgery. The present study aimed to evaluate the ability of iPTH assay to monitor parathyroid function and to identify the risk of postoperative hypocalcemia in pa...

Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry.

International journal of clinical and experimental medicine
It was reported that macitentan was metabolized predominantly by cytochrome P450 3A4, and ACT-132577, its pharmacologically active metabolite, is fivefold less potent at blocking ET receptors than macitentan. In this work, a sensitive and selective u...

Gingipains from Porphyromonas gingivalis promote the transformation and proliferation of vascular smooth muscle cell phenotypes.

International journal of clinical and experimental medicine
The aim of the present study was to ascertain the effect of Porphyromonas gingivalis cysteine protease gingipain on the proliferation of rat aortic smooth muscle cells (RASMCs). Gingipains were isolated and purified from the supernatant of P. gingiva...

Pharmacokinetic and bioavailability study of angeloylgomisin H in rat plasma by UPLC-MS/MS.

International journal of clinical and experimental medicine
Angeloylgomisin H, as a major lignin in the fruits, was reported to have the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ. In this work, a sensitive and selective UPLC-MS/MS method for determination of angeloylgomisin H...

In vitro, ex vivo and in vivo anti-hypertensive activity of Chrysophyllum cainito L. extract.

International journal of clinical and experimental medicine
Chrysophyllum cainito L., a traditional herbal medicine, could have the potential for management of hypertension due to presence of polyphenolic compounds. The extracts and fractions of the pulp of plant were evaluated for in vitro (inhibition of ang...

Influence of cell printing on biological characters of chondrocytes.

International journal of clinical and experimental medicine
OBJECTIVE: To establish a two-dimensional biological printing technique of chondrocytes and compare the difference of related biological characters between printed chondrocytes and unprinted cells so as to control the cell transfer process and keep c...

A new rodent model of cerebral hyperperfusion.

International journal of clinical and experimental medicine
BACKGROUND: Most studies of hyperperfusion and hyperperfusion syndrome after carotid endarterectomy or carotid stenting are based on clinical observation or meta-analyses in patients, whereas there is little corresponding fundamental research since p...

A simple and rapid method for detection of paraquat in human plasma by high-performance liquid chromatography.

International journal of clinical and experimental medicine
We have developed an effective analytical method to determine the concentration of paraquat in human plasma by high-performance liquid chromatography (HPLC), which can provide methodological support for diagnosis, therapy, and prognostic evaluation o...