AIMC Journal:
bioRxiv

Showing 1421 to 1430 of 4956 articles

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence

bioRxiv May 21, 2026
Adolescence is an important developmental period during which there are diverse changes in the brain and behavior. Goal-directed behaviors and the component processes underlying those behaviors improve during adolescence, including working memory, re...
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DeepBioGS: a hybrid framework for integrating crop growth modelling with genomic prediction through neural networks

bioRxiv May 21, 2026
Ensuring global food security under rapid climate change demands accelerated genetic gain and breeding strategies that address complex Genotype-by-Environment (GxE) interactions. Traditional genomic selection models often fail to account for novel or...
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A Bioprinted Head and Neck Cancer Organoid-Based Platform for Evaluating Multimodal Therapies

bioRxiv May 21, 2026
Treatment of advanced head and neck squamous cell carcinoma (HNSCC) often involves radiotherapy combined with chemotherapy, targeted therapy, or immunotherapy. However, due to its anatomical and molecular heterogeneity, identifying the most effective...
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A Systematic Comparison of tTIS Optimization Approaches for Focal Neuromodulation

bioRxiv May 21, 2026
stimulation (tTIS) is a promising non-invasive brain stimulation technique that has the potential to selectively modulate deep brain regions by delivering two high-frequency alternating currents that interfere to produce a low-frequency amplitude-mod...
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Explainable AI reveals the quantitative hierarchical architecture of global bird extinction risk

bioRxiv May 21, 2026
Identifying what makes species vulnerable to extinction requires accounting for complex biological and environmental interactions. Due to their high predictive accuracy, machine learning methods have been widely used for these assessments; however, r...
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Membrane proteomics of the Drosophila circadian neural network

bioRxiv May 21, 2026
Circadian behaviors are controlled by dedicated brain pacemaker neurons, whose activity oscillate during the day and the night. The Drosophila brain contains ca. 240 such neurons. Their molecular clock is synchronized, but the phase of their rhythmic...
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The YTHDF proteins shape the brain gene signatures of Alzheimer's disease

bioRxiv May 20, 2026
The gene signatures of Alzheimer's Disease (AD) brains reflect an output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulation., yet the dominant factor shaping these signatures remains unclear. To ide...
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Discriminative Site-Directed Protein Engineering via Lightweight CASPE Platform

bioRxiv May 20, 2026
Protein large language models (PLMs) provide a novel computational paradigm for the deep mining of sequence co-evolutionary information, significantly accelerating the generation of functional proteins for biotechnological and medical applications. H...
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Assessing the Generalizability of Machine Learning and Physics-Based Methods with DNA-Encoded Libraries

bioRxiv May 20, 2026
Predicting protein-ligand binding is a central challenge in computational drug discovery, and while machine learning (ML) and co-folding methods have advanced rapidly, their ability to generalize beyond training or parameterization regimes remains in...
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Comprehensive interaction profiling and machine learning prediction of bacteriophage infectivity across clinically diverse Pseudomonas aeruginosa

bioRxiv May 20, 2026
The rise of antibiotic-resistant bacterial infections has driven renewed interest in bacteriophage therapy, where viruses that specifically kill bacteria are used as targeted antimicrobials. Pseudomonas aeruginosa, a WHO critical-priority pathogen th...
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