AIMC Journal:
bioRxiv

Showing 2041 to 2050 of 4956 articles

Generative AI-based design of hybrid transcriptional activator proteins with new DNA-binding specificity

bioRxiv Mar 13, 2026
Transcriptional control arises from the specific recognition of promoter DNA by transcription factors (TFs), forming the basis of cellular information processing and gene regulation. In synthetic biology, TF-promoter interactions are assembled into g...
View on bioRxiv DOI

Fleming: An AI Agent for Antibiotic Discovery in Mycobacterium Tuberculosis

bioRxiv Mar 12, 2026
Antibiotic development is challenged by high costs and failure rates. Artificial intelligence (AI) holds promise to overcome these challenges by predicting inhibitory properties of novel compounds, generating new candidates, and contextualizing prope...
View on bioRxiv DOI

Consumption of Reinforcing Solutions Engages Dynamic Activityof the Prelimbic Cortical Outputs

bioRxiv Mar 12, 2026
The medial prefrontal cortex integrates information about salience and valence of stimuli, including rewarding solutions like alcohol and sucrose, and regulates aspects of alcohol seeking and consumption. However, our understanding of how cortical ou...
View on bioRxiv DOI

Genomic streamlining of seagrass-associated Colletotrichum sp. may be related to its adaptation to a marine monocot host

bioRxiv Mar 12, 2026
Colletotrichum spp. have a complicated history of association with land plants. Perhaps most well-known as plant pathogens for the devastating effect they can have on agricultural crops, some Colletotrichum spp. have been reported as beneficial plant...
View on bioRxiv DOI

Eukaryotic MAGs recovered from deep metagenomic sequencing of the seagrass, Zostera marina, include a novel chytrid in the order Lobulomycetales

bioRxiv Mar 12, 2026
Fungi play pivotal roles in terrestrial ecosystems as decomposers, pathogens, and endophytes, yet their significance in marine environments is often understudied. Seagrasses, as globally distributed marine flowering plants, have critical ecological f...
View on bioRxiv DOI

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

bioRxiv Mar 12, 2026
Identifying predictive biomarkers of immunotherapeutic response in melanoma remains an outstanding challenge. Existing transcriptomic and proteomic profiling methods of the tumor-immune microenvironment are costly and may not faithfully capture modif...
View on bioRxiv DOI

Application of large language models to the annotation of cell lines and mouse strains in genomics data

bioRxiv Mar 12, 2026
Accurate, consistent and comprehensive metadata are essential for the reuse of functional genomics data deposited in repositories such as the Gene Expression Omnibus (GEO), however, achieving this often requires careful manual curation that is time-c...
View on bioRxiv DOI

A DNA foundation model predicts osteoporosis risk genes without proximity bias

bioRxiv Mar 12, 2026
Targets supported by human genetic associations are more than twice as likely to progress from clinical development to approval. Genome-wide association studies are the largest source of genetic evidence for disease risk but linking non-coding varian...
View on bioRxiv DOI

Automated morphometry and weight prediction of juvenile Chinook Salmon leveraging open-source deep learning models

bioRxiv Mar 12, 2026
Minimizing handling of threatened and endangered fish has become increasingly important as populations have dwindled. To minimize handling in morphometric measurements, the HandsFreeFishing program has been developed for juvenile Chinook Salmon (Onco...
View on bioRxiv DOI

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine Learning

bioRxiv Mar 12, 2026
Recombinant human Interleukin-2 (rhIL-2, Aldesleukin) is used in immunotherapy for metastatic melanoma and renal cell carcinoma. Low-dose IL-2 has been investigated for administration after adoptive T cell transfer to enhance CAR T expansion and sust...
View on bioRxiv DOI
Popular Topics
Popular Journals