AIMC Journal:
bioRxiv

Showing 561 to 570 of 4935 articles

A structured study of cross-condition prediction of transcriptional responses to gene perturbations

bioRxiv Aug 5, 2026
Gene perturbation experiments coupled with transcriptomic profiling are crucial for uncovering causal gene-gene relationships, yet it remains cost-prohibitive to systematically explore perturbation responses across diverse biological conditions. As a...
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A Comprehensive Database of Simulations and Meshes of Coronary Arteries from the Fame 2 Trial

bioRxiv Aug 5, 2026
In this work, we publish the 3D unsteady Navier-Stokes numerical simulations and meshes of coronary arteries reconstructed from invasive X-ray coronary angiograms acquired during in the Fractional Flow Reserve versus Angiography for Multivessel Evalu...
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Dual-Specific Antibody Design Using Artificial Intelligence

bioRxiv Aug 5, 2026
Multibodies, or "two-in-one" Immunoglobulin G (IgG) antibodies, are standard symmetrical IgG molecules engineered to competitively bind more than one antigen within a single variable fragment (Fv) binding surface. This format merges the functional ad...
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CryoLigATE: enhancing the resolvability of cryo-EM maps in protein-ligand complexes using deep learning

bioRxiv Aug 5, 2026
Cryo-electron microscopy (cryo-EM) has become a central tool for structure-based drug discovery, yet ligand-binding sites often remain substantially less well resolved than the surrounding protein, limiting reliable atomic interpretation. Although de...
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scMaize: A Single-Cell Foundation Model and Integrated Atlas for Maize

bioRxiv Aug 5, 2026
Single-cell transcriptomics has resolved cell type-specific gene expression in plants, yet maize still lacks an integrated reference and species-specific foundation models. We present scMaize, which combines scMaizeAtlas, an integrated atlas of 385,6...
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AI-guided discovery of antimicrobial peptides for urinary tract infections leveraging a new catalogue of the human urinary microbiome

bioRxiv Aug 5, 2026
Urinary tract infections (UTIs) are common infections that pose a critical burden on healthcare and society. Despite growing recognition that the human urinary tract harbors its own microbiome, its composition, functional potential, and alterations i...
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Hoike: A Joint-Embedding Predictive Architecture for Transcriptome Data Generation with Diffusion Models

bioRxiv Aug 5, 2026
In biomarker discovery, access to sufficient quantities of condition-specific transcriptomic data is often limited by cohort size, privacy concerns, and domain shift between normal and condition populations. Generative modeling can augment scarce coh...
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Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

bioRxiv Aug 4, 2026
Alzheimer's disease (AD) causes amyloid formation, neuritic dystrophy, gliosis, synapse loss, behavioral abnormalities, and weight loss. 5xFAD transgenic mice simulate these alterations. To further investigate overall tau reduction as a therapeutic s...
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Structured connectivity for structured sequential computations

bioRxiv Aug 4, 2026
Cortical computations emerge from the coordinated activity of recurrent neural circuits and are often described through population dynamics and neuronal selectivity. However, how the backbone of the computations - the circuit connectivity - gives ris...
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Evolutionary rise of a synaptic mechanism for creating and diversifying key reinforcement signals

bioRxiv Aug 4, 2026
Most neurons release either excitatory or inhibitory neurotransmitters. However, multiple inputs to the lateral habenula (LHb) co-transmit glutamate and GABA, transmitters with opposing effects on LHb output. Although the LHb has an established role ...
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