bioRxiv : the preprint server for biology
May 12, 2025
Müllercell is the most common type of glial cell in the human and mouse retina, playing a crucial role in maintaining retinal homeostasis. In addition to providing structural support to the retina, Müllercells can also supply trophic substances to re...
bioRxiv : the preprint server for biology
Mar 19, 2025
We present a comprehensive map of the metabolomics research landscape, synthesizing insights from over 80,000 publications. Using PubMedBERT, we transformed abstracts into 768-dimensional embeddings that capture the nuanced thematic structure of the ...
bioRxiv : the preprint server for biology
Oct 12, 2024
Motor brain-machine interfaces (BMIs) decode neural signals to help people with paralysis move and communicate. Even with important advances in the last two decades, BMIs face key obstacles to clinical viability. Invasive BMIs achieve proficient curs...
bioRxiv : the preprint server for biology
Dec 28, 2023
SUMMARY: The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded the chemical diversity of small molecules for drug discovery. Selecting compounds f...
bioRxiv : the preprint server for biology
Dec 28, 2023
Predictive modeling has now become a central technique in neuroimaging to identify complex brain-behavior relationships and test their generalizability to unseen data. However, data leakage, which unintentionally breaches the separation between data ...
bioRxiv : the preprint server for biology
Dec 26, 2023
With the advancements in instrumentation, image processing algorithms, and computational capabilities, single-particle electron cryo-microscopy (cryo-EM) has achieved nearly atomic resolution in determining the 3D structures of viruses. The virus str...
bioRxiv : the preprint server for biology
Dec 25, 2023
Deep-brain stimulation (DBS) with implanted electrodes revolutionized treatment of movement disorders and empowered neuroscience studies. Identifying less invasive alternatives to DBS may further extend its clinical and research applications. Nanomat...
bioRxiv : the preprint server for biology
Oct 28, 2020
Perfusion of convalescent plasma (CP) has demonstrated a potential to improve the pneumonia induced by SARS-CoV-2, but procurement and standardization of CP are barriers to its wide usage. Many monoclonal antibodies (mAbs) have been developed but app...