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Corynebacterium glutamicum

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Predicting pupylation sites in prokaryotic proteins using semi-supervised self-training support vector machine algorithm.

Analytical biochemistry
As one important post-translational modification of prokaryotic proteins, pupylation plays a key role in regulating various biological processes. The accurate identification of pupylation sites is crucial for understanding the underlying mechanisms o...

Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model-driven process analysis.

Biotechnology and bioengineering
Given its geometric similarity to large-scale production plants and the excellent possibilities for precise process control and monitoring, the classic stirred tank bioreactor (STR) still represents the gold standard for bioprocess development at a l...

High cell density cultivation of Corynebacterium glutamicum by deep learning-assisted medium design and the subsequent feeding strategy.

Journal of bioscience and bioengineering
To improve the cell productivity of Corynebacterium glutamicum, its initial specific growth rate was improved by medium improvement using deep neural network (DNN)-assisted design with Bayesian optimization (BO) and a genetic algorithm (GA). To obtai...