AIMC Topic: CRISPR-Associated Protein 9

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Learning to utilize internal protein 3D nanoenvironment descriptors in predicting CRISPR-Cas9 off-target activity.

NAR genomics and bioinformatics Jun 1, 2025
Despite advances in determining the factors influencing cleavage activity of a CRISPR-Cas9 single guide RNA (sgRNA) at an (off-)target DNA sequence, a comprehensive assessment of pertinent physico-chemical/structural descriptors is missing. In partic...
Machine Learning CRISPR-Cas Systems Mutation Gene Editing RNA, Guide, CRISPR-Cas Systems CRISPR-Associated Protein 9
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Machine learning predicts new anti-CRISPR proteins.

Nucleic acids research May 21, 2020
The increasing use of CRISPR-Cas9 in medicine, agriculture, and synthetic biology has accelerated the drive to discover new CRISPR-Cas inhibitors as potential mechanisms of control for gene editing applications. Many anti-CRISPRs have been found that...
Machine Learning Proteome Bacterial Proteins Streptococcus Sequence Analysis, Protein CRISPR-Associated Protein 9 Prophages
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