AI Medical Compendium

Decoding Allosteric Inhibition in MALT1: The Hidden Role of Conformational Plasticity in Metastable States via Biased MD and Deep Learning.

The journal of physical chemistry. B Jan 20, 2026

The mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is a key protein in the adaptive immune response system in humans. This protein is widely expressed in the human body and is related to nuclear factor-κB (NF-κB) signaling... read more

No deep insights into the alignment between human and deep learning reasoning processes: Thoughts on de Varda et al. (2025).

Proceedings of the National Academy of Sciences of the United States of America Jan 20, 2026

Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history.

Proceedings of the National Academy of Sciences of the United States of America Jan 20, 2026

The transition from anaerobic to aerobic life was a pivotal adaptation in Earth's history, yet the timing and genomic drivers remain poorly resolved. Traditional approaches relying on oxygen-utilizing genes need improvement for obligate anaerobes and... read more

Learning a Pairwise Epigenomic and Transcription Factor Binding Association Score Across the Human Genome.

Bioinformatics (Oxford, England) Jan 20, 2026

MOTIVATION: Identifying pairwise associations between genomic loci is an important challenge for which large and diverse collections of epigenomic and transcription factor (TF) binding data can potentially be informative. RESULTS: We developed Learni... read more

Two Decades of Metaphorical Use of Schizophrenia in Brazilian Newspapers: A Machine Learning Approach.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Jan 20, 2026

Media representation of mental illness has the potential to reinforce stigma. This phenomenon may arise from the perpetuation of stereotypes, the association of mental disorders with violent conduct, or the use of a diagnosis in a metaphorical applic... read more

Ambient Air Pollution, Greenness and Frailty in an Elder Asian Population: A Multi-Center Study with Long-Term Exposure.

The journals of gerontology. Series A, Biological sciences and medical sciences Jan 20, 2026

BACKGROUND: Long-term exposure to air pollution has been linked to adverse health outcomes in older adults; however, its association with frailty, particularly the potential protective role of environmental factors such as greenness, remains insuffic... read more

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences.

Bioinformatics (Oxford, England) Jan 20, 2026

SUMMARY: The accurate development, assessment, interpretation, and benchmarking of bioinformatics frameworks for analyzing transcriptional regulatory grammars rely on controlled simulations to validate the underlying methods. However, existing simula... read more

Program Theory and Core Outcome Set Development for a Technology-Assisted Counseling Intervention in Dementia: Multimethods Study.

Journal of medical Internet research Jan 20, 2026

BACKGROUND: Counseling in family dementia care aims to support caregivers in mastering challenges. The use of information and communication technologies (ICT) to administer counseling can improve accessibility. Evidence syntheses report inconsistent ... read more

Humans Female Male Dementia Caregivers Counseling

Quantifying Innovation in Stroke: Large Language Model Bibliometric Analysis.

Journal of medical Internet research Jan 20, 2026

BACKGROUND: Thrombolysis and mechanical thrombectomy represent the most successful stroke innovations over the last 30 years. Quantifying innovation in stroke is essential for identifying productive research lines and prioritizing funding, but health... read more

Humans Language Bibliometrics Stroke Large Language Models Patents as Topic

Adaptive geometric-attention multi-task framework with knowledge distillation for aortic dissection detection in non-contrast CT.

Physics in medicine and biology Jan 20, 2026

Aortic dissection (AD) is a life-threatening cardiovascular emergency. Non-contrast-enhanced CT (NCE-CT) could provide timely AD screening with fewer contraindications compared to contrast-enhanced CT angiography (CE-CT). However, NCE-CT examinations... read more

Artificial Intelligence Medical Compendium