International journal of medical informatics
Dec 27, 2025
OBJECTIVE: This study aimed to create and validate a machine learning (ML) model to predict the likelihood of invasive mechanical ventilation (IMV) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by r... read more
Difficult-to-treat rheumatoid arthritis (D2T RA) is an emerging challenge in aging populations, where disease persistence and therapeutic failure often reflect not only autoimmune dysregulation but also the cumulative effects of age-related biologica... read more
International journal of medical informatics
Dec 27, 2025
INTRODUCTION: This paper explores the potential benefits and limitations of synthetic data (SD) in paediatrics, addressing the challenges of data scarcity and privacy concerns in paediatric research. METHODOLOGY: A narrative literature review was con... read more
This study explores the network pharmacology (NP) and molecular dynamics (MD) simulation analysis of pleural mesothelioma (PM) related enzymes. Through the investigation of 1253 associated genes, culminating in a protein-protein interaction (PPI) net... read more
Drug-Target Affinity (DTA) prediction is critical for reducing failure rates in drug discovery, but existing deep learning methods often trade efficiency for accuracy. Existing CNN-LSTM methods for DTA have convolutional neural networks (CNNs) and lo... read more
PURPOSE: The number of adolescents and young adults (AYAs) with cancer has increased over the past 30 years. Fundamental to this process has been the combined contribution from nursing and other health care professionals. METHODS: The authors discuss... read more
Food research international (Ottawa, Ont.)
Dec 27, 2025
Non-Saccharomyces yeasts have been shown to enhance and diversify the aroma profile of cider. This study aimed to elucidate the regulatory role of inorganic nitrogen and to improve cider aroma quality by investigating how the type and concentration o... read more
This study developed a new alternative Agtron detection system using a low-cost multichannel spectral sensor (410-940 nm) combined with classical and modern chemometric regression methods, and implemented the selected model in an embedded system to p... read more
Under intense therapeutic stress-including chemotherapy, radiotherapy, and targeted therapies-tumor cells can undergo ploidy reprogramming to generate polyploid giant cancer cells (PGCCs). Once largely overlooked, this rare but biologically distincti... read more
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