Recent advances in Large Language Models (LLMs) offer new assessment approaches that can help overcome the limitations of traditional Likert-item scales in measuring complex, subjective constructs. To demonstrate this, we introduce and validate a nov... read more
The journal of prevention of Alzheimer's disease
Oct 30, 2025
BACKGROUND: The rapid increase in the incidence of Alzheimer's disease (AD) has raised concerns, given its profound effects on both society and the economy. Despite extensive research efforts in this area, there are no existing treatments that have t... read more
OBJECTIVES: This study aims to achieve accurate differentiation of malignant pleural mesothelioma (MPM) from metastatic pleural disease (MPD) and to predict the overall survival of MPM. MATERIALS AND METHODS: This IRB-approved retrospective study inc... read more
Recently, with the rapid advancement of multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, new tools and approaches have been introduced for studying nerve injury and regeneration. This review highlights the ... read more
Dysregulated proteome in the retina represents a promising avenue for discovering novel therapeutic targets and noninvasive diagnostic biomarkers for neurodegenerative diseases with ocular manifestations. Advanced mass spectrometry-based proteomics t... read more
BACKGROUND: Periodontitis (PD) is a chronic inflammatory disease marked by immune dysregulation and progressive tissue destruction. Macrophages play a pivotal role in PD pathogenesis; however, their heterogeneity, molecular characteristics and clinic... read more
Acute hepatopancreatic necrosis disease (AHPND) poses a major threat to global shrimp aquaculture, especially impacting Penaeus vannamei. Given the high cost of prevention and the absence of effective treatments, the most efficient way to control AHP... read more
Identifying reliable links between individual differences in neurobiological features and differences in symptom profiles or treatment outcomes is a primary goal of precision psychiatry. In this context, brain-behavior predictive modeling has emerged... read more
Age-related macular degeneration (AMD) is one of the most common types of eye diseases that generally affect the elderly population over 50 years of age. The effects of AMD on the quality of vision and life are devastating. We systematically review a... read more
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