OBJECTIVES: Large-scale radiographic datasets often include errors in labels such as body parts or projection, which can undermine automated image analysis. Therefore, we aimed to develop and externally validate two deep-learning models-one for categ... read more
OBJECTIVES: High-resolution vessel wall imaging (HR-VWI) is essential for diagnosing vulnerable intracranial atherosclerotic plaques, but its interpretation requires expertise. This study investigates the integration of large language models (LLMs) a... read more
Journal of chemical information and modeling
Oct 22, 2025
Accurate prediction of protein-ligand binding affinity is vital for accelerating drug discovery, yet challenges persist in efficiently capturing critical structural and chemical interactions efficiently. This study introduces amino acid pair position... read more
Molecular dynamics simulations hold great promise for providing insight into the microscopic behavior of complex molecular systems. However, their effectiveness is often constrained by long timescales associated with rare events. Enhanced sampling me... read more
OBJECTIVES: Traumatic dental injuries (TDIs) are complex clinical conditions that require timely and accurate decision-making. With the rise of large language models (LLMs), there is growing interest in their potential to support dental management. T... read more
BackgroundThe incidence of anastomotic leakage (AL) following radical gastrectomy for gastric cancer ranges from 2.1% to 14.6%, with mortality rates up to 50%. Existing predictive methods lack both timeliness and accuracy. This study aimed to develop... read more
PURPOSE: Time-dependent diffusion MRI enables quantification of tumor microstructural parameters useful for diagnosis and prognosis. Nevertheless, current model fitting approaches exhibit suboptimal bias-variance trade-offs; specifically, nonlinear l... read more
Pancreatic disease affects over 10% of the world population, and the most dangerous is pancreatic cancer (PC). The disease is mostly of late age of onset, especially in developed countries, and is associated with poor prognosis due to late presentati... read more
PURPOSE OF REVIEW: Osteochondrosis encompasses a heterogenous group of pathologies affecting endochondral ossification in the growing child and adolescent. The cause of each disease is multifactorial, though many are often related to overuse injury, ... read more
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