AI Medical Compendium

MealRes-Gate: Forecasting Glucose Dynamics from CGM and Sparse Meal Logs Using Residual-Gated Multimodal Transformer

medRxiv Jun 3, 2026

Continuous glucose monitoring (CGM) enables personalized metabolic health support, but forecasting glucose in free-living settings remains challenging because future trajectories depend on both endogenous dynamics and sparsely recorded meals. We deve... read more

health informatics

sstar2: A Python Package for S*-based Archaic Introgression Detection with Machine Learning

bioRxiv Jun 3, 2026

Detecting introgressed genomic fragments from unsampled or extinct source populations remains challenging. The S* statistic is widely used for this purpose, but the original sstar implementation relies on generalized additive models to smooth quantil... read more

bioinformatics

ORIGAMI: Orientation-Aware Graph Neural Network for Assessing Multimeric Interfaces of Protein Complex Structures

bioRxiv Jun 3, 2026

Deep learning-based protein structure prediction methods have led to a paradigm-shift in computational structural biology, yet reliably assessing the quality of computationally predicted multimeric structures remains challenging. Recent methods have ... read more

bioinformatics

AdventML: Advanced Enzyme Temperature Prediction with Transformer-Based Embeddings and Resampling Strategies

bioRxiv Jun 3, 2026

Accurate prediction of enzymes' optimal catalytic temperature (Topt) is crucial in biotechnology, as enzymes with extreme Topt values are highly desirable for reactions at extreme temperatures and for their general stability. However, experimental de... read more

bioinformatics

CodeCytos: AI-assisted spatial molecular imaging analysis via code-augmented agent action space

bioRxiv Jun 3, 2026

Conventional tissue image analysis software provides foundational capabilities for cellular analysis, including segmentation, morphological feature extraction, and spatial organization analysis; however, these tools often require manual intervention ... read more

bioinformatics

SciCore-Omics: a tri-modal foundation model unifying histology, spatial transcriptomics and language for spatial biology

bioRxiv Jun 3, 2026

Histomorphology and spatial transcriptomics capture complementary aspects of tissue biology, but their relationships remain difficult to extract, align, and interpret at scale. Existing foundation models typically connect histology, omics, or languag... read more

bioinformatics

HyperNiche: Learning Heterophilic Cellular Niches with Hypergraph Neural Networks

bioRxiv Jun 3, 2026

We propose HyperNiche, a hypergraph-based framework for modeling higher-order, heterogeneous cellular niches from spatial transcriptomics data. Unlike conventional graph-based methods that rely on pairwise similarity and tend to produce homogeneous c... read more

bioinformatics

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups

bioRxiv Jun 3, 2026

T-cell acute lymphoblastic leukemia (T-ALL) comprises molecularly diverse subtypes, but robust cross-cohort validations and operational gene-expression definitions are lacking. To establish a gene-expression-anchored framework for T-ALL subtyping, we... read more

bioinformatics

MAGI: Mechanistic Consequences of Genetic Variants via Genomic Foundation Models

bioRxiv Jun 3, 2026

Clinical variant interpretation requires mechanism-aware evidence to guide diagnosis and clarify the biological consequences of mutations. However, existing computational predictors and genomic foundation models largely function as black boxes, provi... read more

genetics

To RAG, or Not to RAG? A Comparative Evaluation of Retrieval-Augmented Generation for ICD Coding of German Tumor Diagnoses

medRxiv Jun 3, 2026

Introduction Coding tumor diagnoses from free-text clinical documentation currently requires substantial manual effort. Promising approaches for automating this process include large language mod-els (LLMs), embedding models, and retrieval-augmented ... read more

health informatics

Artificial Intelligence Medical Compendium

MealRes-Gate: Forecasting Glucose Dynamics from CGM and Sparse Meal Logs Using Residual-Gated Multimodal Transformer

sstar2: A Python Package for S*-based Archaic Introgression Detection with Machine Learning

ORIGAMI: Orientation-Aware Graph Neural Network for Assessing Multimeric Interfaces of Protein Complex Structures

AdventML: Advanced Enzyme Temperature Prediction with Transformer-Based Embeddings and Resampling Strategies

CodeCytos: AI-assisted spatial molecular imaging analysis via code-augmented agent action space

SciCore-Omics: a tri-modal foundation model unifying histology, spatial transcriptomics and language for spatial biology

HyperNiche: Learning Heterophilic Cellular Niches with Hypergraph Neural Networks

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups

MAGI: Mechanistic Consequences of Genetic Variants via Genomic Foundation Models

To RAG, or Not to RAG? A Comparative Evaluation of Retrieval-Augmented Generation for ICD Coding of German Tumor Diagnoses

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