Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning.

Journal: EBioMedicine
Published Date:

Abstract

BACKGROUND: Deployment and access to state-of-the-art precision medicine technologies remains a fundamental challenge in providing equitable global cancer care in low-resource settings. The expansion of digital pathology in recent years and its potential interface with diagnostic artificial intelligence algorithms provides an opportunity to democratize access to personalized medicine. Current digital pathology workstations, however, cost thousands to hundreds of thousands of dollars. As cancer incidence rises in many low- and middle-income countries, the validation and implementation of low-cost automated diagnostic tools will be crucial to helping healthcare providers manage the growing burden of cancer.

Authors

  • Divya Choudhury
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
  • James M Dolezal
    Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
  • Emma Dyer
    Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
  • Sara Kochanny
    Department of Medicine, University of Chicago Medicine, Chicago, IL, USA.
  • Siddhi Ramesh
    Pritzker School of Medicine, University of Chicago, Chicago, IL.
  • Frederick M Howard
    Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Jayson R Margalus
    DePaul University, Idea Realization Lab, Chicago, IL, USA.
  • Amelia Schroeder
    DePaul University, Idea Realization Lab, Chicago, IL, USA.
  • Jefree Schulte
    Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Marina C Garassino
    Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
  • Jakob N Kather
    Department of Gastroenterology, University Hospital RWTH Aachen, Aachen, Germany. jakob.kather@gmail.com.
  • Alexander T Pearson
    Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.