The use of artificial neural networks in studying the progression of glaucoma.

Journal: Scientific reports
PMID:

Abstract

In ophthalmology, artificial intelligence methods show great promise due to their potential to enhance clinical observations with predictive capabilities and support physicians in diagnosing and treating patients. This paper focuses on modelling glaucoma evolution because it requires early diagnosis, individualized treatment, and lifelong monitoring. Glaucoma is a chronic, progressive, irreversible, multifactorial optic neuropathy that primarily affects elderly individuals. It is important to emphasize that the processed data are taken from medical records, unlike other studies in the literature that rely on image acquisition and processing. Although more challenging to handle, this approach has the advantage of including a wide range of parameters in large numbers, which can highlight their potential influence. Artificial neural networks are used to study glaucoma progression, designed through successive trials for near-optimal configurations using the NeuroSolutions and PyTorch frameworks. Furthermore, different problems are formulated to demonstrate the influence of various structural and functional parameters on the study of glaucoma progression. Optimal neural networks were obtained using a program written in Python using the PyTorch deep learning framework. For various tasks, very small errors in training and validation, under 5%, were obtained. It has been demonstrated that very good results can be achieved, making them credible and useful for medical practice.

Authors

  • Filip Târcoveanu
    Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115, Iasi, Romania.
  • Florin Leon
    "Gheorghe Asachi" Technical University of Iasi, Faculty of Automatic Control and Computer Engineering, Department of Computer Engineering, 27 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.
  • Cătălin Lisa
    "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection "Cristofor Simionescu", Department of Chemical Engineering, Bd. Prof.dr.doc Dimitrie Mangeron No. 73, Iasi 700050, Romania. Electronic address: clisa@ch.tuiasi.ro.
  • Silvia Curteanu
    "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Chemical Engineering, 73 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.
  • Andreea Feraru
    Faculty of Economic Science, "Vasile Alecsandri" University of Bacau, Calea Marasesti 156, 600115, Bacau, Romania.
  • Kashif Ali
    Countess of Chester Hospital, Liverpool Rd, Chester, CH21UL, UK.
  • Nicoleta Anton
    Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115, Iasi, Romania. nicolofta@gmail.com.