Tauopathies are characterised by a progressive accumulation of hyperphosphorylated tau. However, early and intermediate stages remain challenging to quantify due to subtle and heterogeneous morphological characteristics. This study evaluates a deep l...
OBJECTIVES: This study aimed to develop and validate a prediction model for the future progression of difficult-to-treat rheumatoid arthritis (D2T RA) and support the precise use of biologic and targeted synthetic disease-modifying antirheumatic drug...
BACKGROUND: Despite the predictive impact of circulating tumor DNA (ctDNA) minimal residual disease (MRD), accurate prediction of failure risk after curative-intent treatments for early-stage or localized non-small cell lung cancer (NSCLC) patients t...
BACKGROUND: Machine learning (ML) has been investigated for its predictive value in knee osteoarthritis (KOA) progression. However, systematic evidence on the effectiveness of ML is still lacking, posing a challenge to precision prevention.
Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant liver cancer with limited treatment options. Recent evidence implicates lactate metabolism as playing a crucial role in tumor progression, but its precise contribution in iCCA remains uncle...
Prostate cancer (PCa) progression is driven by complex molecular reprogramming, yet distinguishing indolent from aggressive disease remains a challenge. We performed an integrative transcriptomic analysis of 1232 PCa samples spanning normal prostate ...
This study aimed to utilize various machine learning algorithms to develop a predictive model for the progression of severe community-acquired pneumonia (SCAP) in children to critical severe community-acquired pneumonia (cSCAP). Retrospective analysi...
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with accelerated lung function decline and increased mortality. However, early and accurate diagnosis remains clinically challenging due to nonspecific s...
Parkinson's disease is one of the most common and complex neurodegenerative diseases, characterized by remarkable motor and cognitive decline. As it is a highly heterogeneous disorder, i.e., the specific symptoms, their severity, and their progressio...
Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are debilitating diseases with unpredictable progression. Artificial Intelligence-based tools for modelling disease progression could significantly improve the quality of life for patien...
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