Perspectives on current approaches to virtual screening in drug discovery.

Journal: Expert opinion on drug discovery
PMID:

Abstract

INTRODUCTION: For the past two decades, virtual screening (VS) has been an efficient hit finding approach for drug discovery. Today, billions of commercially accessible compounds are routinely screened, and many successful examples of VS have been reported. VS methods continue to evolve, including machine learning and physics-based methods.

Authors

  • Ingo Muegge
    Alkermes, Inc, Waltham, Massachusetts, USA.
  • Jörg Bentzien
    Research department, Alkermes, Inc, Waltham, MA, USA.
  • Yunhui Ge
    Research department, Alkermes, Inc, Waltham, MA, USA.