Drug combinations are essential to modern medicine, but their discovery remains slow and inefficient as experimental complexity expands rapidly with each additional drug tested. Although modern liquid handling systems enable complex and highly custom...
Journal of the American Chemical Society
Nov 26, 2025
The implementation of high-throughput methods for fuelling the design of effective nanocarriers for RNA delivery remains challenging. Traditional experimental screening is resource-intensive, while purely computational approaches face limitations, su...
Journal of chemical information and modeling
Nov 21, 2025
Transferable biomolecular force fields are developed by fitting either ab initio or experimental data related to representative molecules and can then be used to model chemical entities that are similar to the ones they were developed for. However, o...
Chemicals with developmental and reproductive toxicity (DART) pose significant risks to human health, particularly exposure during critical windows of embryonic and fetal development. Therefore, rapid and accurate identification of DART chemicals is ...
Rational design of signal peptides (SPs), crucial for efficient therapeutic protein secretion in Chinese hamster ovary (CHO) cells, remains challenging due to their context-dependency activity. To overcome this limitation and enable the discovery of ...
Self-organised three-dimensional (3D) cell cultures, collectively called 3D-oids, include spheroids, organoids and other co-culture models. Systematic evaluation of these models forms a critical new generation of high-content screening (HCS) systems ...
Journal of chemical information and modeling
Sep 12, 2025
The rapid expansion of chemical space presents significant challenges in identifying novel ligands for drug targets. Here, we introduce BIOPTIC B1, an ultra-high-throughput ligand-based virtual screening system capable of rapidly evaluating multi-bil...
In recent years, silica nanoparticles have garnered tremendous attention as drug-delivery carriers. However, the cell permeability of nanoparticles remains a major obstacle that limits the drug-delivery efficiency of drug carriers. It is a common pra...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aug 2, 2025
Despite therapeutic advancements, metastatic and nonmetastatic castration-resistant prostate cancer (mCRPC and nmCRPC) remain incurable due to drug resistance, partly due to Androgen receptor (AR) gene abnormalities and splice variants. An Augmented ...
Colorectal cancer (CRC) treatment remains challenging due to genetic heterogeneity and resistance mechanisms. To address this, we developed a drug discovery pipeline using patient-derived primary CRC cultures with diverse genomic profiles. These cult...
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