Machine learning predicts pulmonary Long Covid sequelae using clinical data.

Journal: BMC medical informatics and decision making
PMID:

Abstract

Long COVID is a multi-systemic disease characterized by the persistence or occurrence of many symptoms that in many cases affect the pulmonary system. These, in turn, may deteriorate the patient's quality of life making it easier to develop severe complications. Being able to predict this syndrome is therefore important as this enables early treatment. In this work, we investigated three machine learning approaches that use clinical data collected at the time of hospitalization to this goal. The first works with all the descriptors feeding a traditional shallow learner, the second exploits the benefits of an ensemble of classifiers, and the third is driven by the intrinsic multimodality of the data so that different models learn complementary information. The experiments on a new cohort of data from 152 patients show that it is possible to predict pulmonary Long Covid sequelae with an accuracy of up to . As a further contribution, this work also publicly discloses the related data repository to foster research in this field.

Authors

  • Ermanno Cordelli
    Unit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, 00128, Italy.
  • Paolo Soda
    Unit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Italy; Department of Radiation Sciences, Radiation Physics, Biomedical Engineering, Umeå, University, Umeå, Sweden. Electronic address: paolo.soda@umu.se.
  • Sara Citter
    Fondazione Bruno Kessler, Via Sommarive, 18, Trento, 38123, Italy.
  • Elia Schiavon
    DeepTrace Technologies S.R.L., Via Conservatorio 17, Milan, 20122, MI, Italy.
  • Christian Salvatore
  • Deborah Fazzini
    Unit of Diagnostic Imaging and Stereotactic Radiotherapy, Centro Diagnostico Italiano S.p.A., Via Saint Bon 20, 20147, Milan, Italy.
  • Greta Clementi
    Department of Diagnostic Imaging and Stereotactic Radiosurgey, Centro Diagnostico Italiano S.p.A., Via S. Saint Bon 20, Milan, 20147, Italy.
  • Michaela Cellina
    Radiology Department, Fatebenefratelli Hospital, Milano, Italy.
  • Andrea Cozzi
    Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Luigi Mangiagalli 31, 20133 Milano, Italy. Electronic address: andrea.cozzi1@unimi.it.
  • Chandra Bortolotto
    Unit of Imaging and Radiotherapy, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Lorenzo Preda
    Unit of Imaging and Radiotherapy, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Luisa Francini
    Unit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, 00128, Italy.
  • Matteo Tortora
    Unit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, 00128, Italy.
  • Isabella Castiglioni
  • Sergio Papa
    Unit of Diagnostic Imaging and Stereotactic Radiotherapy, Centro Diagnostico Italiano S.p.A., Via Saint Bon 20, 20147, Milan, Italy.
  • Diego Sona
    NeuroInformatics Laboratory (NILab), Fondazione Bruno Kessler, Trento, Italy; Pattern Analysis and Computer Vision, Istituto Italiano di Tecnologia, Genova, Italy.
  • Marco Ali
    Unit of Diagnostic Imaging and Stereotactic Radiotherapy, Centro Diagnostico Italiano S.p.A., Via Saint Bon 20, 20147, Milan, Italy.