Novel design of fractional cholesterol dynamics and drug concentrations model with analysis on machine predictive networks.
Journal:
Computers in biology and medicine
PMID:
39579668
Abstract
Within the intricate fabric of human physiology, cholesterol, a lipid present in cell membranes exerts a discernible effect on the concentration of the drug in human body that influence the aspects of drug pharmacokinetics. The objective of this work is to design a case study based fractional order cholesterol drug interaction model that encapsulates the nuanced dynamics inherent in the multifaceted human physiology with identification of essential variables including drug concentration K and cholesterol level γ. The strength of nonlinear autoregressive with exogenous inputs (NARX) neural networks are exploited to predict the temporal dynamics that reveal the hidden intricacies and subtle patterns within the fractional model. Grünwald-Letnikov (GL) based fractional solver is used to generate the synthetic data, serving as a robust foundation for training, testing and validation of the NARX neural networks for different use cases of cholesterol drug interaction control strategies. A thorough comparative analysis based on exhaustive simulation unveiled a marginal distinction between the results obtained from NARX and the outcomes of fractal technique showing remarkably low MSE in the range of 10. The strength of the designed methodology is further verified by using other performance metrics such as MSE, regression index, autocorrelation and cross correlation. The integration of genetic and genomic information tailor the model to address the unique characteristics of individual patient facilitating advancement in precision medicines.