Biochemical and biophysical research communications
Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Journal of chemical information and modeling
Nov 6, 2025
The sigma-2 receptor (σR/TMEM97) is a clinically relevant membrane protein involved in cholesterol regulation and overexpressed in cancer and neurodegenerative diseases. Despite its therapeutic potential, the dynamic mechanisms underlying σR function...
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Cholesterol metabolism-related genes (CMRGs) have been associated with osteoarthritis (OA), but their specific regulatory mechanisms remain unclear. This study aimed to investigate the role of CMRGs in OA and provide new insights into its treatment. ...
We present a comprehensive, quantitative model of the allosteric molecular mechanisms of selective cholesterol (CHL) uptake and delivery by the StarD4 protein - an intracellular cholesterol trafficking protein that facilitates the crucial non-vesicul...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Apr 9, 2025
To achieve rapid, cost-efficient, convenient and accurate detection of five clinical serum biochemical indexes, namely glucose (GLU), triglycerides (TG), total cholesterol (TC), total protein (TP) and albumin (ALB), ultraviolet-visible-near infrared ...
BACKGROUND: With the rising diagnostic rate of gallbladder polypoid lesions (GPLs), differentiating benign cholesterol polyps from gallbladder adenomas with a higher preoperative malignancy risk is crucial. This study aimed to establish a preoperativ...
Within the intricate fabric of human physiology, cholesterol, a lipid present in cell membranes exerts a discernible effect on the concentration of the drug in human body that influence the aspects of drug pharmacokinetics. The objective of this work...
In this paper, the first e-nose system coupled with machine learning algorithm for noninvasive measurement of total cholesterol level based on exhaled air sample was proposed. The study was conducted with the participation of 151 people, from whom a ...
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Oct 25, 2024
BACKGROUND: This study aimed to understand the collective impact of trace elements, vitamins, cholesterol, and prealbumin on patient outcomes in the intensive care unit (ICU) using an advanced artificial intelligence (AI) model for mortality predicti...
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