MIU-Net: Advanced multi-scale feature extraction and imbalance mitigation for optic disc segmentation.

Journal: Neural networks : the official journal of the International Neural Network Society
PMID:

Abstract

Pathological myopia is a severe eye condition that can cause serious complications like retinal detachment and macular degeneration, posing a threat to vision. Optic disc segmentation helps measure changes in the optic disc and observe the surrounding retina, aiding early detection of pathological myopia. However, these changes make segmentation difficult, resulting in accuracy levels that are not suitable for clinical use. To address this, we propose a new model called MIU-Net, which improves segmentation performance through several innovations. First, we introduce a multi-scale feature extraction (MFE) module to capture features at different scales, helping the model better identify optic disc boundaries in complex images. Second, we design a dual attention module that combines channel and spatial attention to focus on important features and improve feature use. To tackle the imbalance between optic disc and background pixels, we use focal loss to enhance the model's ability to detect minority optic disc pixels. We also apply data augmentation techniques to increase data diversity and address the lack of training data. Our model was tested on the iChallenge-PM and iChallenge-AMD datasets, showing clear improvements in accuracy and robustness compared to existing methods. The experimental results demonstrate the effectiveness and potential of our model in diagnosing pathological myopia and other medical image processing tasks.

Authors

  • Yichen Xiao
    Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address: yichenxiao@fudan.edu.cn.
  • Yi Shao
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Disease, Shanghai, China.
  • Zhi Chen
    Duke University.
  • Ruyi Zhang
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R.China.
  • Xuan Ding
    Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China.
  • Jing Zhao
    Department of Pharmacy, Pharmacoepidemiology and Drug Safety Research Group, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
  • Shengtao Liu
    Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address: 505560283@qq.com.
  • Teruko Fukuyama
    Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address: Teru5255@hotmail.com.
  • Yu Zhao
    College of Agriculture, Shanxi Agricultural University, Taigu, Shanxi, China.
  • Xiaoliao Peng
    Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. Electronic address: 22111260012@m.fudan.edu.cn.
  • Guangyang Tian
    Australian AI Institute, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW 2007, Australia. Electronic address: guangyang.tian@student.uts.edu.au.
  • Shiping Wen
  • Xingtao Zhou
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.