A deep learning method to integrate extracelluar miRNA with mRNA for cancer studies.

Journal: Bioinformatics (Oxford, England)
Published Date: Nov 1, 2024

Abstract

MOTIVATION: Extracellular miRNAs (exmiRs) and intracellular mRNAs both can serve as promising biomarkers and therapeutic targets for various diseases. However, exmiR expression data is often noisy, and obtaining intracellular mRNA expression data usually involves intrusive procedures. To gain valuable insights into disease mechanisms, it is thus essential to improve the quality of exmiR expression data and develop noninvasive methods for assessing intracellular mRNA expression.

Authors

  • Tasbiraha Athaya
    Department of Computer Science, University of Central Florida, Orlando, Florida, United States of America.
  • Xiaoman Li
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, USA. xiaoman@mail.ucf.edu.
  • Haiyan Hu
    Department of Computer Science, University of Central Florida, Orlando, FL, USA. haihu@cs.ucf.edu.

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