Quantitative analysis of the dexamethasone side effect on human-derived young and aged skeletal muscle by myotube and nuclei segmentation using deep learning.

Journal: Bioinformatics (Oxford, England)
PMID: 39752317

Abstract

MOTIVATION: Skeletal muscle cells (skMCs) combine together to create long, multi-nucleated structures called myotubes. By studying the size, length, and number of nuclei in these myotubes, we can gain a deeper understanding of skeletal muscle development. However, human experimenters may often derive unreliable results owing to the unusual shape of the myotube, which causes significant measurement variability.

Authors

  • Seonghwan Park
    Daegu Gyeongbuk Institute of Science and Technology, Department of Robotics Engineering, Dalseong-gu, Republic of Korea.
  • Min Young Kim
    Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
  • Jaewon Jeong
    Department of Robotics and Mechatronics Engineering, DGIST, Daegu, 42988, South Korea.
  • Sohae Yang
    Department of New Biology, DGIST, Daegu, 42988, South Korea.
  • Minseok S Kim
    Department of New Biology, DGIST, Daegu, 42988, South Korea.
  • Inkyu Moon
    Daegu Gyeongbuk Institute of Science and Technology, Department of Robotics Engineering, Dalseong-gu, Republic of Korea.

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