Multiplexed methods for the detection of protein expression generate extremely data-rich images of intact tissue sections. These images are invaluable for the quantification and analysis of complex biology and biomarker development. However, their in...
In histological pathology, frozen sections are often used for rapid diagnosis during surgeries, as they can be produced within minutes. However, they suffer from artifacts and often lack crucial diagnostic details, particularly within the cell nuclei...
Breast cancer remains a leading cause of morbidity and mortality worldwide. Histopathology, particularly the analysis of nuclear morphology in tissue samples, is critical for diagnosing and understanding the progression of breast cancer. Accurate nuc...
Accurate nuclei segmentation and classification in histology images are critical for cancer detection but remain challenging due to color inconsistency, blurry boundaries, and overlapping nuclei. Manual segmentation is time-consuming and labor-intens...
Cellular senescence is an irreversible state of cell cycle arrest with a complex role in tissue repair, aging, and disease. However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significanc...
Various diseases including laminopathies and certain types of cancer are associated with abnormal nuclear mechanical properties that influence cellular and nuclear deformations in complex environments. Recently, microgroove substrates designed to mim...
Cutaneous melanoma is one of the most lethal forms of skin cancer, and its incidence is increasing globally. Its diagnosis typically relies on manual histopathological examination, a process that is both complex and time consuming. In this study, we ...
Multiplexed imaging techniques require identifying different cell types in the tissue. To utilize their potential for cellular and molecular analysis, high throughput and accurate analytical approaches are needed in parsing vast amounts of data, part...
International journal of molecular sciences
May 24, 2025
Traumatic brain injury (TBI) triggers a cascade of molecular and cellular disturbances, including apoptosis, inflammation, and destabilization of neuronal connections. The transcription factor p53 plays a pivotal role in regulating cell fate followin...
IEEE journal of biomedical and health informatics
May 6, 2025
Segmentation of cell nuclei from three-dimensional (3D) volumetric fluorescence microscopy images is crucial for biological and clinical analyses. In recent years, convolutional neural networks have become the reliable 3D medical image segmentation s...
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